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SOPs

Standard Operating Procedures (SOPs) provides end-users with clear instructions on how to work and develop enough to ensure that all end-users can perform their tasks in a consistent and consistent manner. Many processes can be difficult, and it is important to have a balance between too few and too many points. If there are too few points, the end-user will follow their path. On the other hand, too much information and too much detail increase the risk that the end-user will struggle to understand and perform everyday steps, resulting in errors and omissions.

Sops are of different types like Quality Control SOPs, General  SOPs, Production SOps, R&D, Regulatory and Validation SOPs etc

Montelukast Sodium Testing Procedure

Montelukast Sodium Testing Procedure

Testing Methods, Raw Material, SOPs
Montelukast Sodium Testing Procedure and Raw Material specification & analysis prescribes the requirements with UV Spectrophotometer spectrum and Alternate Method of Analysis on HPLC System and Other Testing procedures. Characters Spread about 1.0 of sample on a clean, dry watch glass and observe the appearance, it should be white crystalline powder and determination. Solubility (i) Take approximately 0.5 gram of sample into a clean test tube containing water. Close the test tube with stopper and shake well. The sample slightly soluble in water. (ii) Take approximately 0.5 gram of sample into a clean test tube containing alcohol. Close the test tube with stopper and shake well. The sample slightly soluble in alcohol. (iii) Take approximately 0.5 gram of sample into a clean tes...
How To Test Naproxen Sodium Raw Material

How To Test Naproxen Sodium Raw Material

Testing Methods, Raw Material, SOPs
How To Test Naproxen Sodium Raw Material specification & analysis prescribes the requirements with UV Spectrophotometer spectrum and Alternate Method of Analysis on HPLC System and Other Testing procedures. Characters How To Test Naproxen Sodium Raw Material Spread about 1.0 of sample on a clean, dry watch glass and observe the appearance, it should be white to creamy crystalline powder Solubility Soluble in water and in methanol; sparingly soluble in alcohol; very slightly soluble in acetone; and practically insoluble in chloroform and in toluene. Melting point Melts at about 225 °C with determination decomposition Procedure: Grind the Naproxen Sodium sample into a fine powder in a mortar and pack the capillary tube with sample by tapping on a hard surface so as to form a...
Paracetamol Raw Material Testing By UV Method

Paracetamol Raw Material Testing By UV Method

Testing Methods, Raw Material, SOPs
Paracetamol Raw Material Testing By UV Method specification & analysis prescribes the requirements with UV Spectrophotometer spectrum and Alternate Method of Analysis on HPLC System and Other Testing procedures. Paracetamol Raw Material Testing By UV and Purpose This raw material specification & analysis prescribes the requirements for Paracetamol raw material Testing UV and HPLC Method. Characters Spread about 1.0 of sample on a clean, dry watch glass and observe the appearance, determination it should be white, crystalline powder. Solubility Sparingly soluble in water, freely soluble in alcohol, very slightly soluble in methylene chloride. Identification Melting point:- 168 °C to 172 °C Procedure: Paracetamol Raw Material Testing By UV Method, Grind the Paracetamol s...
Ranitidine HCl Testing UV and HPLC Method

Ranitidine HCl Testing UV and HPLC Method

Testing Methods, Raw Material, SOPs
Ranitidine HCl Testing UV and HPLC Method Raw Material specification & analysis prescribes the requirements with UV Spectrophotometer spectrum and Alternate Method of Analysis on HPLC System and Other Testing procedures. Ranitidine HCl Testing UV and HPLC Method and Purpose This raw material specification & analysis prescribes the requirements for Ranitidine HCl raw material Testing UV and HPLC Method. Characters Ranitidine HCl Testing UV and HPLC Method is spread about 1.0 of sample on a clean, dry watch glass and observe the appearance, it should be white to pale yellow, crystalline, practically odorless powder. Is sensitive to light and moisture. Melts at about 140º, with decomposition. Solubility Ranitidine HCl Very soluble in water; sparingly soluble in alcohol. Melt...
Calibration SOPs for UV Spectrophotometer

Calibration SOPs for UV Spectrophotometer

SOPs
Calibration is one of the most frequently used techniques in pharmaceutical analysis. This involves measuring the amount of ultraviolet radiation or seen absorbed by a substance in the solution. The calibration instrument measures the ratio, or function ratio, from the intensity of two light beams in Qualitative UV analysis, organic compounds can be identified using spectrophotometers, if there are recorded data available, and quantitative spectrophotometric analysis is used to ensure the quantity of molecular species that absorb radiation. Calibration of spectrophotometric techniques are simple, fast, quite specific and applies to small quantities of compounds. Fundamental law that regulates calibration spectrophotometrically analysis PURPOSE: To describe the Calibration procedure for...
Operational SOPs for UV/VIS Spectrophotometer

Operational SOPs for UV/VIS Spectrophotometer

SOPs
UV/VIS Spectrophotometer Operational SOPs method is used to measure the pharmaceutical and non-pharmaceutical compounds that have detectable peaks in the UV-Vis region PURPOSE: To describes the operating procedure for operation of UV/VIS Spectrophotometer. SCOPE: This SOP gives detailed outline for the operation of UV/VIS Spectrophotometer and will cover operating procedure of equipment. RESPONSIBILITY: QC Analyst is responsible for operation of equipment and preparing standard operating procedure. It is the responsibility of QC Manager to assist and ensure Operating Procedure’s as per SOP and to make certain that this SOP is followed in its entirety, reviewed regularly and revised as necessary. REFERENCE:                                       In-House Specifications MATE...
HPLC Waters Pda With Quartnary Pump – SOPs

HPLC Waters Pda With Quartnary Pump – SOPs

SOPs
This SOP HPLC WATERS PDA WITH QUARTNARY PUMP most important who gives a detailed outline for the operation of HPLC 1 Waters PDA With Quartnary Pump and will cover the operating procedure, calibration and cleaning of equipment. PURPOSE:                      To describes the operating procedure for operation of HPLC 1 Waters PDA With Quartnary Pump. SCOPE:                    This SOP gives detailed outline for the operation of HPLC 1 Waters PDA With Quartnary Pump and will cover operating procedure, calibration and cleaning of equipment. RESPONSIBILITY: QC Analyst is responsible for the operation of equipment and preparing standard operating procedures. It is the responsibility of QC Manager to assist and ensure Operating Procedure as per SOP and to make certain that this SOP is ...

Cleaning SOPs for UV Spectrophotometer

SOPs, Quality Control
In this article detail is given of Cleaning SOPs for UV Spectrophotometer, how to clean UV Spectrophotometer in Quality control Laboratory of Pharmaceuticals. OBJECTIVE To lay down the procedure for cleaning of UV/VIS Spectrophotometer. SCOPE: This shall be applicable to the UV/VIS Spectrophotometer installed in Quality Control instrument Laboratory. RESPONSIBILITY: Technical Assistant/ Helper. C Analyst. ACCOUNTABILITY: Manager-Quality Control. MATERIAL AND EQUIPMENT: UV/VIS Spectrophotometer. Clean dry cloth. Tissue paper. Dilute soap solution. Purified water. PROCEDURE: Ensure that the power supply to the instrument is switched OFF before cleaning. After completion of the testing, remove cuve...
Washing Of HPLC Column SOP

Washing Of HPLC Column SOP

SOPs
Here is the WASHING OF HPLC COLUMN, it is very important in the laboratory, if not done can correctly affect the health of your column. Cleaning your HPLC column may be simple, but it is very important for efficiency, lifetime, and productivity instruments. The ineffective HPLC column can affect your analysis, resulting in inaccurate results, which means more time spent on the same project. The following SOP focuses only on how to clean your HPLC column through reverse flushing. It may be time to water your HPLC column when you see high back pressure, low efficiency, split peak, or the most common problem, the particulate buildup in the head of the column. Now we move to Washing Of HPLC Column SOP Objective:            This method is applicable for washing of HPLC column.      Sco...

Operational SOPs for HPLC (High Performance Liquid Chromatography)

SOPs
In this post, we will study Operational SOPs for HPLC (High Performance Liquid Chromatography).  All the related outline, scope, responsiblity and procedure you will study here. 1.      PURPOSE To outline work instruction for “HPLC” in Quality Control Department. 2.      SCOPE To separation of different material in solution in Quality Control Department. 3.      RESPONSIBILITY All analysts are responsible to follow the instruction.    4.      PROCEDURE 4.1   Instrument Information Name  HPLC Identification No. Model (Pump)                   L-2100/2130 Model (UV-VIS Detector)   L-2420 Range wave length           190-900 nm Operating Temp. Range     15 ºC to 25 ºC           4.2 Method of Operation Connect the instrument to power supply. Switch on...