All Posts - Pharma Egg

Jan32022 by KBS.1 Comment

Operational SOPs for HPLC (High Performance Liquid Chromatography)

SOPs

In this post, we will study Operational SOPs for HPLC (High Performance Liquid Chromatography). All the related outline, scope, responsiblity and procedure you will study here. 1. PURPOSE To outline work instruction for “HPLC” in Quality Control Department. 2. SCOPE To separation of different material in solution in Quality Control Department. 3. RESPONSIBILITY All analysts are responsible to follow the instruction. 4. PROCEDURE 4.1 Instrument Information Name HPLC Identification No. Model (Pump) L-2100/2130 Model (UV-VIS Detector) L-2420 Range wave length 190-900 nm Operating Temp. Range 15 ºC to 25 ºC 4.2 Method of Operation Connect the instrument to power supply. Switch on...

Jan32022 by KBS.No Comments

Melting Point Apparatus use in Pharmaceuticals

Quality Control

Pharmaceutical Melting Point Apparatus equipment is designed to quickly measure the Melting range and point of certain substances. Some samples can be tested simultaneously and safely in the analyzer of the Bench-Top Melting point. Purchasing considerations for Pharmaceutical Laboratory Melting Point Analyzer includes the temperature range of instruments, user interfaces, and test heating times. Melting point apparatus is a laboratory device used to determine the melting point of an element with precision and large accuracy. The temperature in which the state of a substance changes from solid to the liquid is said to be the melting point. Melting a substance is generally obtained by heating it. This is one of the most important and basic parameters to know about the nature of a substanc...

Jan32022 by KBS.No Comments

Disintegration Apparatus use in Pharmaceuticals Industry

Quality Control

Disintegration Apparatus testers are used to test how drugs in the form of pellets will be destroyed in solution. Like the testers of dissolution, they allow researchers and medical practitioners to analyze in vitro details of powder compounds for quality control purposes. Standard disintegration tester A.S. Pharmacopeia uses three baskets with round mesh (or mesh sample tube), which slowly moved up and down in the water bath at 37 ° C. The tablet is placed in the basket of the disintegration tester and the time taken for them destroyed; Or, disintegration testers can be used for pass / failed to see if the tablet will dissolve completely, if at all. Simple tools such as disintegration testers must be assessed with their relative compactness, the quality and accuracy of their temperature c...

Jan32022 by KBS.No Comments

ph Meter use in Pharmaceuticals

Quality Control

The pH is a measure of alkalinity& an aqueous solution’s acidity. This is dependent on the comparative number of hydrogen ions (H+) or hydroxyl ions (OH-) in the solution. Higher relative number of hydrogen ions; conversely, alkaline solutions have a higher relative number of OH- ions in acidic solution. In water, the absorption of H+ and OH‑ may vary over 15 orders of magnitude. The Henderson–Hasselbalch equation allows pH to be derived from the quantity of H+ using pKa, the negative log of the acid dissociation constant, in biological and chemical systems. Most of the Pharmaceuticalsas part of their process measure pH to assure product quality. A pH meter is a scientific instrument that measures the hydrogen ion activity in water-based solutions, indicating its acidity or alkalinit...

Jan32022 by KBS.No Comments

FTIR Spectrometer (Fourier Transform) use in Pharmaceuticals

Quality Control

Pharmaceutical Quality Control Laboratories face strong regulatory requirements and market pressure at each step along the product development pipes. FTIR Spectrometer (Fourier Transform) is one of the best equipment for pharmaceutical analysis because it is easy to use, every analyst can easily use this FTIR easily and learn quickly to operate it, fast, and helps ensure regulatory compliance through the validation protocol. A Guide to FTIR Analysis & FTIR Applications Infrared spectroscopy is a versatile method for determining fingerprints and identification of pharmaceutical compounds and functional groups in molecules. It measures energy absorption in the infrared frequency range. Pharmaceutical samples of gas, liquid, or solid can be analyzed by infrared spectroscopy. The Four...

Jan12022 by KBS.1 Comment

UV Spectrophotometers use in Pharmaceuticals

Quality Control

UV spectrophotometers can analyze organic compounds in pharmaceuticals today. Qualitative information provided convinced the patient's health and safety. Qualitative analysis of organic compounds can be achieved through a simple process of UV spectrophotometry. UV spectrophotometer measures the areas seen from ultraviolet light and can provide valuable information about the level of active ingredients in pharmaceutical compounds, and detect impurities. By measuring the absorption of UV light radiation, spectrophotometric analysis can measure these levels at a very accurate level. This chapter includes the use of spectrophotometry in the pharmaceutical industry. Applications where these spectroscopic techniques are used contributing significantly to analytical processes. For example,...

Jan12022 by KBS.2 Comments

HPLC (High Performance Liquid Chromatography) use in Pharmaceuticals

Quality Control

HPLC use in Pharmaceuticals HPLC is a liquid chromatography form commonly used in the pharmaceutical industry, because it can provide the exact results needed. HPLC (High Performance Liquid Chromatography) use in Pharmaceuticals is increasing day by day. The results can be used to analyze drug products and the materials are quantitative and qualitatively during the manufacturing process. Liquid chromatography is an analytical technique used widely in the pharmaceutical industry. How does it work and what method can be combined to increase its use? High performance liquid chromatography (HPLC) is a very useful analytical technique with various applications. HPLC involves the adsorbent material column (such as silica beads) where the sample is forwarded under pressure. Each sample mixtur...